Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 138, Issue 2, Pages 217-220Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2141.2007.06636.x
Keywords
B-chronic lymphocytic leukaemia; trisomy 19; trisomy 12; cytogenetics; IgVH genes
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Funding
- MRC [MC_U132670597] Funding Source: UKRI
- Medical Research Council [MC_U132670597] Funding Source: researchfish
- Medical Research Council [MC_U132670597] Funding Source: Medline
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The occurrence of trisomy 19 was investigated in 705 cases of B-chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (16%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV genes. In contrast, B-CLL cases with trisomy 12 lacking trisomy 19 mostly had unmutated IGHV genes. Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B-CLL with trisomy 12, mostly originating from mutated B cells.
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