Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 13, Pages 7280-7285Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00406-07
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Human immunodeficiency virus type 2 (HIV-2) strains vary widely in their abilities to grow in Old World monkey (OWM) cells such as those of cynomolgus monkeys (CM). We evaluated eight HIV-2 isolates for their sensitivities to CM TRIM5 alpha, an anti-HIV factor in OWM cells. We found that different HIV-2 isolates showed differences in their sensitivities to CM TIUWa. Sequence analysis showed that TRIM5ot-sensitive viruses had proline at the 120th position of the capsid protein (CA), whereas TRIM15 alpha-resistant viruses had either alanine or glutamine. Mutagenesis studies indicated that the single amino acid at the 120th position indeed affected the sensitivity of the virus to CM TRIM5 alpha.
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