Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 138, Issue 1, Pages 72-76Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2141.2007.06627.x
Keywords
aplastic anaemia; T cells; bone marrow failure
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Funding
- Intramural NIH HHS Funding Source: Medline
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In aplastic anaemia, T cells have a central role in the pathophysiology of bone marrow destruction. This study showed that T cells from patients with aplastic anaemia expressed decreased T-cell receptor (TCR) zeta-chain protein and mRNA levels compared to healthy controls. Patients with decreased TCR zeta-chain showed an abnormal response in intracellular calcium following stimulation through the TCR. We also observed an altered pattern of the transcription factors CREM alpha and Elf-1 that are implicated in zeta-chain transcription. We concluded that TCR zeta-chain expression was decreased in the majority of patients with aplastic anaemia, regardless of disease activity or treatment status.
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