Journal
MICROBES AND INFECTION
Volume 9, Issue 9, Pages 1135-1138Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2007.04.012
Keywords
CCR5; Yersinia pestis; plague; host resistance
Categories
Funding
- NIAID NIH HHS [R21 AI 59689, P30 AI051445, U54 AI 057157, AI 065641, P30 AI 51445, R21 AI065641, R21 AI059689, U54 AI057157] Funding Source: Medline
- NIGMS NIH HHS [GM 070977, R01 GM070977-01A1, R37 GM070977, R01 GM070977] Funding Source: Medline
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CCR5 is a chemokine receptor used by HIV-1 to enter cells and has recently been found to act as a pathogen associated molecule pattern receptor. Current positive selection for the high frequency of a CCR5-Delta 32 allele in humans has been attributed to resistance to HIV, smallpox, and plague infections. Using an intranasal mouse model of Y. pestis infection, we have found that lack of CCR5 does not enhance host resistance to Y. pestis infection and that CCR5-mediated responses might have a protective role. CCR5-/- mice exhibited higher levels of circulating RANTES and MIP-l alpha than those exhibited by wild-type mice at the baseline and throughout the course of Y. pesos infection. High levels of RANTES and MIP-l alpha, which are CCR5 ligands that mediate Natural Killer cell migration, may reflect compensation for the absence of CCR5 signaling. (C) 2007 Elsevier Masson SAS. All rights reserved.
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