Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 85, Issue 7, Pages 666-671Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/Y07-050
Keywords
airway function; airway hyperresponsiveness; airway smooth muscle; airway wall remodelling; asthma; extracellular matrix; integrins; phenotype plasticity
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The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway wall. This review provides a brief overview of the current understanding of the biology associated with airway smooth muscle interactions with the extracellular matrix. We present future directions needed for the study of cellular and molecular mechanisms that determine the outcomes of extracellular matrix - airway smooth muscle interactions, and discuss their possible importance as determinants of airway function in asthma.
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