Journal
ANALYTICAL CHEMISTRY
Volume 80, Issue 8, Pages 2805-2810Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac702403w
Keywords
-
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/C511572/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/C511572/1] Funding Source: researchfish
Ask authors/readers for more resources
Oligonucleotide-gold nanoparticle (OGN) conjugates are powerful tools for the detection of target DNA sequences due to the unique properties conferred upon the oligonucleotide by the nanoparticle. Practically all the research and applications of these conjugates have used gold nanoparticles to the exclusion of other noble metal nanoparticles. Here we report the synthesis of oligonucleotide-silver nanoparticle (OSN) conjugates and demonstrate their use in a sandwich assay format. The OSN conjugates have practically identical properties to their gold analogues and due to their vastly greater extinction coefficient both visual and absorption analyses can occur at much lower concentrations. This is the first report of OSN conjugates being successfully used for target DNA detection and offers improved sensitivity which is of interest to a range of scientists.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available