Journal
NATURE GENETICS
Volume 39, Issue 7, Pages 827-829Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2058
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Funding
- Medical Research Council [G0000934] Funding Source: Medline
- Wellcome Trust [068545/Z/02, GR068094MA, 068094] Funding Source: Medline
- Medical Research Council [G0000934] Funding Source: researchfish
- MRC [G0000934] Funding Source: UKRI
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We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding ( rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109- TENR- IL2- IL21 linkage disequilibrium block. We independently confirmed association in two further collections ( strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(- 14), odds ratio 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
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