Journal
INTENSIVE CARE MEDICINE
Volume 33, Issue 7, Pages 1243-1251Publisher
SPRINGER
DOI: 10.1007/s00134-007-0661-8
Keywords
edema clearance; hypoxia; coagulation; catecholamines; dopamine; protein trafficking
Categories
Funding
- NHLBI NIH HHS [R37 HL048129, P01 HL071643, HL-71643, HL-48129, R01 HL048129, HL-65161, R01 HL065161] Funding Source: Medline
Ask authors/readers for more resources
Active transport of sodium across the alveolar epithelium, undertaken in part by the Na,K-adenosine triphosphatase (Na,K-ATPase), is critical for clearance of pulmonary edema fluid and thus the outcome of patients with acute lung injury. Acute lung injury results in disruption of the alveolar epithelial barrier and leads to impaired clearance of edema fluid and altered Na,K-ATPase function. There has been significant progress in the understanding of mechanisms regulating alveolar edema clearance and signaling pathways modulating Na,K-ATPase function during lung injury. The accompanying review by Morty et al. focuses on intact organ and animal models as well as clinical studies assessing alveolar fluid reabsorption in alveolar epithelial injury. Elucidation of the mechanisms underlying regulation of active Na+ transport, as well as the pathways by which the Na,K-ATPase regulates epithelial barrier function and edema clearance, are of significance to identify interventional targets to improve outcomes of patients with acute lung injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available