4.2 Article

Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus

Journal

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 144, Issue 1, Pages 53-56

Publisher

SPRINGER
DOI: 10.1007/s10517-007-0252-2

Keywords

silymarin; succinic acid; streptozotocin; liver mitochondria

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Silymarin (70 mg/kg) and succinic acid (50 mg/kg) reduce blood glucose and cholesterol concentrations, inhibit LPO, and correct oxidative phosphorylation disturbances in liver mitochondria in experimental diabetes mellitus induced by injection of streptozotocin (65 mg/kg) in rats.

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