Journal
NEUROIMAGE
Volume 36, Issue 3, Pages 630-644Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2007.02.049
Keywords
diffusion tensor imaging; tractography; reproducibility; white matter
Funding
- NCRR NIH HHS [P41 RR015241, P41 RR015241-01A1, U24 RR021382-01, U24 RR021382, P41RR15241, U24RR021382] Funding Source: Medline
- NIA NIH HHS [R01 AG020012-06A1, R01 AG020012-05, R01AG20012, R01 AG020012-02, R01 AG020012-04, R01 AG020012-01, R01 AG020012-03, R01 AG020012] Funding Source: Medline
- NIBIB NIH HHS [P41 EB015909] Funding Source: Medline
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Tractography based on diffusion tensor imaging (DTI) allows visualization of white matter tracts. In this study, protocols to reconstruct eleven major white matter tracts are described. The protocols were refined by several iterations of intra- and inter-rater measurements and identification of sources of variability. Reproducibility of the established protocols was then tested by raters who did not have previous experience in tractography. The protocols were applied to a DTI database of adult normal subjects to study size, fractional anisotropy (FA), and T-2 of individual white matter tracts. Distinctive features in FA and T-2 were found for the corticospinal tract and callosal fibers. Hemispheric asymmetry was observed for the size of white matter tracts projecting to the temporal lobe. This protocol provides guidelines for reproducible DTI-based tract-specific quantification. (c) 2007 Elsevier Inc. All rights reserved.
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