Journal
ANALYTICAL CHEMISTRY
Volume 80, Issue 24, Pages 9700-9704Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac801675r
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Funding
- Korea Research Foundation, Republic of Korea
- Biosignal Analysis Technology Innovation program [M10645010002-06N450100210]
- Ministry of Education and Science, Republic of Korea
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A time-of-flight mass spectrometer equipped with two reflectrons was constructed for multiplexed photodissociation tandem mass spectrometry of peptide ions generated by matrix-assisted laser desorption ionization. A linear reflectron was used for high-resolution selection of a precursor ion while a quadratic reflectron was used for product ion analysis. With the photoexcitation of a precursor ion inside a cell floated at high voltage, information (MS3) on intermediate ions generating a particular product ion was obtained. Fully multiplexed detection resulted in good MS' signal levels. Use of the quadratic reflectron allowed intermediate ion mass determination within 4 Da. The possibility of further extending the technique and its analytical potential are discussed.
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