Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 94, Issue 3, Pages 320-335Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2006.04.001
Keywords
Kir channels; PIP2; regulation; Co-factors
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Funding
- NHLBI NIH HHS [R37 HL60025] Funding Source: Medline
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All members of the inwardly rectifying potassium channels (Kirl-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP2). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (K-ATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na+ ions. Recent studies have demonstrated that PIP, acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP2 and co-factors modulate channel activities in each subfamily of the Kir channels. (c) 2006 Elsevier Ltd. All rights reserved.
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