Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 30, Issue 7, Pages 1336-1339Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.30.1336
Keywords
curcumin; embryotoxicity; zebrafish
Categories
Ask authors/readers for more resources
Embryotoxic and teratogenic effects of curcumin on the development of zebrafish embryo were investigated in this study. The LD50 values of curcumin (24-h incubation) were estimated at 7.5,mu m and 5,mu m for embryos and larvae, respectively. The developmental defects caused by curcumin treatments include bent or hook-like tails, spinal column curving, edema in pericardial sac, retarded yolk sac resorption, and shorter body length. In curcumin-treated larvae, fluorescence signals of curcumin were found in edamae sac and some skin cells. Together, these results indicate that zebrafish are suitable model organisms to study the toxic effects of curcumin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available