Journal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume 36, Issue 6, Pages 1451-1463Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2015.2390
Keywords
CCN family proteins; receptors; signalling pathways; cell functions; cancers
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Funding
- Cancer Research Wales
- Cardiff China Medical Research Collaborative (CCMRC)
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The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been identified in various types of cancer. Perturbed expression of CCNs has been observed in a variety of malignancies. The aberrant expression of certain CCNs is associated with disease progression and poor prognosis. Insight into the detailed mechanisms involved in CCN-mediated regulation may be useful in understanding their roles and functions in tumorigenesis and cancer metastasis. In this review, we briefly introduced the functions of CCNs, especially in cancer.
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