Metabolic syndrome and chronic kidney disease in a Chinese population aged 40 years and older

OBJECTIVE: To explore the relationship between metabolic syndrome and chronic kidney disease (CKD) in a study population from a developing country. PARTICIPANTS AND METHODS: The prevalence of metabolic syndrome (as most recently defined by the International Diabetes Federation) and CKD (defined as an estimated glomerular filtration rate of < 60 mL/min per 1.73 M2 and/or albuminuria) was determined in 2310 study participants (age >= 40 years) from Beijing, China, between May 12 and December 7, 2004. The relationship between metabolic syndrome and CKD was then analyzed. RESULTS: Participants with metabolic syndrome had a higher prevalence of CKD (15.4% vs 8.3%; P <.001) than those without the syndrome. As the number of metabolic syndrome traits increased, so did the prevalence of CKD. Strong unadjusted and adjusted associations were observed between metabolic syndrome and CKD. For participants without hypertension and diabetes, metabolic syndrome was also associated with CKD (odds ratio, 2.03; 95% confidence interval, 1.05-3.94). CONCLUSION: In these 2310 Chinese,study participants aged 40 years and older, metabolic syndrome was associated with CKD.