Journal
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
Volume 21, Issue -, Pages 31-35Publisher
WILEY
DOI: 10.1111/j.1365-3016.2007.00835.x
Keywords
pre-eclampsia; change in partner; paternity; statistical artefact; pregnancy; interval
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Immunology has been hypothesised to play a critical role in the development of pre-eclampsia. A number of epidemiological studies have shown that multiparous women who changed partner had an increased risk of pre-eclampsia in the following pregnancy compared with multiparous women with the same partner. However, partner change is often associated with a long birth interval. Two recent papers using data from the same birth registry reported that, after controlling for birth interval, partner change was associated with a reduced risk of pre-eclampsia. Based on a causal diagram, the author argues conceptually that birth interval is not a confounder but more likely to be a collider. Controlling for or stratifying birth interval in the association between partner change and risk of pre-eclampsia could be inappropriate and may have produced a spurious association.
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