Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 79, Issue 7, Pages 919-921Publisher
WILEY-BLACKWELL
DOI: 10.1002/jmv.20816
Keywords
HBIG; passive prophylaxis; indications for HBIG
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Specific hepatitis B immune globulin (HBIG) contains a high titer of antibody to hepatitis B surface antigens and provides immediate passive protection against infection with hepatitis B virus, after acute exposure to infection. It is now generally combined with active immunization with hepatitis B vaccine. The principal indications for administration of HBIG are: a single acute percutaneous exposure to hepatitis B virus (HBV); mucocutaneous exposure; unprotected sexual exposure; mother-to-infant transmission; prevention of re-infection after liver transplantation; non-responders to hepatitis B vaccine and immunosuppressed patients.
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