Silica-supported aluminum chloride: A recyclable and reusable catalyst for one-pot three-component Mannich-type reactions

Silica-supported aluminum chloride was used as an efficient, recyclable and reusable catalyst for the one-pot Mannich-type reactions of acetophenone with aromatic aldehydes and aromatic amines. This protocol has advantages of high yield, mild condition, no environmental pollution, and simple work-up procedure. (c) 2007 Elsevier B.V. All rights reserved.