4.4 Article

Enantioselective transaminations by dendrimeric enzyme mimics

Journal

TETRAHEDRON
Volume 63, Issue 27, Pages 6317-6321

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.02.052

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Funding

  1. NIGMS NIH HHS [R01 GM018754-39] Funding Source: Medline

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PAMAM dendrimers have been constructed with a pyridoxamine core and chiral capping amino groups. Transamination to form phenylalanine and alanine from their related keto acids produced enantioselectivities induced by the formally remote chiral caps, supporting computer models that indicate folding of the dendrimer chains back into the core region. (c) 2007 Elsevier Ltd. All rights reserved.

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