Journal
BIOCHEMISTRY
Volume 46, Issue 26, Pages 7665-7677Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi700338m
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Funding
- NIGMS NIH HHS [R56 GM056444, GM56444, R01 GM056444, GM62884, R01 GM056444-08, R01 GM056444-09, R01 GM062884] Funding Source: Medline
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To be activated by cell surface G protein-coupled receptors, heterotrimeric G proteins must localize at the cytoplasmic surface of plasma membranes. Moreover, some G protein subunits are able to traffic reversibly from the plasma membrane to intracellular locations upon activation. This current topic will highlight new insights into how nascent G protein subunits are assembled and how they arrive at plasma membranes. In addition, recent reports have increased our knowledge of activation-induced trafficking of G proteins. Understanding G protein assembly and trafficking will lead to a greater understanding of novel ways that cells regulate G protein signaling.
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