Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 14, Pages 5457-5460Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo0707535
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The dual Lewis acid/base catalytic system, generated from N-methylimidazole (NMI), (R)-1,1'-bi-2-naphthol [(R)-BINOL], and Ti(OiPr)(4), effectively catalyzes the enantioselective alkynylation of aldehydes in the presence of Et2Zn in good yields and excellent enantioselectivities of up to 94% ee at room temperature. The mild reaction conditions make it possible to use functional alkynes in this asymmetric addition.
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