New catalysts for Suzuki-Miyaura coupling reactions of heteroatom-substituted heteroaryl chlorides

The new air-stable PdCl2{PR2(Ph-R')}(2) complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids. The coupling reactions catalyzed by the new complexes exhibit high product yields (88-99%) and high catalyst turnover numbers (up to 10 000 TON).