Journal
ANALYTICAL BIOCHEMISTRY
Volume 426, Issue 1, Pages 40-46Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2012.03.024
Keywords
CdS quantum dots (QDs); Molecularly imprinted technique; Electrochemical sensor; Urea
Funding
- National High Technology Research and Development Program of China [2009AA03Z217]
- National Natural Science Foundation of China [20955001, 21175049, 90922028]
- Natural Science Foundation of Fujian Province of China [2011J01049]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars (Ministry of Education, China)
- Fundamental Research Funds for the Central Universities [10QZR13]
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An improved imprinted film-based electrochemical sensor for urea recognition was developed using CdS quantum dots (QDs) doped chitosan as the functional matrix. The microstructure and composition of the imprinted films depicted by scanning electron microscopy (SEM), attenuated total reflection infrared (ATR-IR). X-ray diffraction (XRD), and electrochemical impedance spectroscopy (EIS) indicated the fabricated feasibility of the nanoparticle doped films via in situ electrodeposition. Differential pulse voltammetric responses under the optimal fabrication conditions showed that the sensitivity of CdS QDs-MIP (molecularly imprinted polymer) electrochemical sensor was enhanced from the favorable electron transfer and magnified surface area of CdS QDs with a short adsorption equilibrium time (7 min), wide linear range (5.0 x 10(-12) to 4.0 x 10(-10) M and 5.0 x 10(-10) to 7.0 x 10(-8) M), and low detection limit (1.0 x 10(-12) M). Meanwhile, the fabricated sensor showed excellent specific recognition to template molecule among the structural similarities and coexistence substances. Furthermore, the proposed sensor was applied to determine the urea in human blood serum samples based on its good reproducibility and stability, and the acceptable recovery implied its feasibility for practical application. (C) 2012 Elsevier Inc. All rights reserved.
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