Journal
FEBS LETTERS
Volume 581, Issue 17, Pages 3164-3170Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.05.082
Keywords
nuclear pore; protein nuclear translocation; diffusion limit
Funding
- NCI NIH HHS [CA054807, CA034432, R01 CA054807, R01 CA034432, R01 CA054807-17, R01 CA034432-22] Funding Source: Medline
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It has generally been believed that the diffusion limit set by the nuclear pore for protein is 60 kDa. We here studied the cellular localization of several artificial proteins and found that the diffusion limit set by the nuclear pore is not as small as previously thought. The results indicate that the maximal size of protein to diffuse through the nuclear pore complex could be quite larger than 60 kDa, thus greatly extending the diffusion limit that the nuclear pore can accommodate. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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