Journal
FEBS LETTERS
Volume 581, Issue 17, Pages 3327-3331Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.06.026
Keywords
GNE; isoforms; sialic acid; splice variants; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine; kinase
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The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme of the biosynthesis of sialic acids, terminal components of glycoconjugates associated with a variety of cellular processes. Two novel isoforms of human GNE, namely GNE2 and GNE3, which possess extended and deleted N-termini, respectively, were characterized. GNE2 was also found in other species like apes, rodents, chicken or fish, whereas GNE3 seems to be restricted to primates. Both, GNE2 and GNE3, displayed tissue specific expression patterns, therefore may contribute to the complex regulation of sialic acid metabolism. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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