Journal
BIOLOGY DIRECT
Volume 2, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1745-6150-2-19
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The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell- cell junctions and, through regulated intra- membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals.
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