Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 59, Issue 6, Pages 419-426Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2007.04.005
Keywords
absorption; bioavailability enhancement; oral drug delivery; nanosuspension; rat; nanomedicine; nanotechnology
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An increasing number of newly developed drugs show bioavailability problems due to poor water solubility. Formulating the drugs as nanosuspensions may help to overcome these problems by increasing saturation solubility and dissolution velocity. In the present study the bioavailability of the poorly soluble fenofibrate following oral administration was investigated in rats. Four formulations were tested: a nanosuspension type DissoCube((R)), one solid lipid nanoparticle (SLN) preparation and two suspensions of micronized fenofibrate as reference formulations, one suspension in sirupus simplex and a second in a solution of hydroxyethy-cellulose in physiological saline. Both colloidal drug delivery systems showed approximately two-fold bioavailability enhancements in terms of rate and extent compared to the reference formulations. No significant differences were found in AUC(0-22) h as well as in C-max and t(max) between the two colloidal delivery systems. In conclusion, nanosuspensions may be a suitable delivery system to improve the bioavailability of drugs with low water solubility. (c) 2007 Elsevier B.V. All rights reserved.
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