Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 28, Pages 7476-7481Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1083-07.2007
Keywords
inhibitory avoidance; spatial novelty; behavioral tag; hippocampus; long-term memory; rats
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A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memory-promoting effect caused by novelty depends on activation of dopamine D-1/D-5 receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace.
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