Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 358, Issue 4, Pages 1136-1141Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.05.062
Keywords
insulin-like growth factor 1 (IGF-1) receptor; presenilin; gamma-secretase; regulated intramembrane proteolysis
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Several type-1 membrane proteins undergo regulated intramembrane proteolysis resulting in the generation of biologically active protein fragments. Presenilin-dependant gamma-secretase activity is central to this event and includes amyloid precursor protein (APP), Notch and ErbB4 as substrates. Here we show that the inslulin-like growth factor I receptor (IGF-IR) undergoes regulated intramembrane Proteolysis. A metalloprotease-dependant ectodomain-shedding event generates a similar to 52 kDa IGF-IR-carboxyl terminal domain (CTD). The IGF-IR-CTD is consequentially a substrate for gamma-secretase cleavage, liberating a similar to 50 kDa intracellular domain (ICD) that can be inhibited by a specific gamma-secretase inhibitor. This study suggests that the IGF-IR is a substrate for gamma-secretase and may mediate a function independent of its role as a receptor tyrosine kinase. (C) 2007 Elsevier Inc. All rights reserved.
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