Journal
CELL CYCLE
Volume 6, Issue 14, Pages 1692-1695Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.6.14.4478
Keywords
TSC; Rheb; mTOR; Tor2; fission yeast
Categories
Funding
- NCI NIH HHS [CA41996] Funding Source: Medline
Ask authors/readers for more resources
The TSC/Rheb/TOR signaling pathway plays important roles in growth and cell cycle regulation. The main player TOR belongs to the PI3K- related protein kinase family. Recent studies utilizing fission yeast Tor2 have led to the identification of a number of amino acid changes that lead to inactivation as well as activation of TOR kinase. Also, constitutive active mutations in its upstream regulator, Rheb, have been identified. Isolation and characterization of temperature sensitive Tor2 mutants have established that this kinase functions as a key switch that determines cell fate between growth and sexual development. Introduction of Tor2 activating mutations into mTOR conferred nutrient independent activation of mTOR. Interestingly, these studies point to regions of TOR kinase important for its function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available