Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 155, Issue 2, Pages 173-177Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2007.01.005
Keywords
magnetic resonance imaging; genetic polymorphisms; hippocampus; temporal lobe
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Funding
- NIMH NIH HHS [R01 MH 57027, K23 MH 65939, K23 MH065939-05, R01 MH057027-05, R01 MH057027, K23 MH065939] Funding Source: Medline
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We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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