4.4 Article

Ruthenium-catalysed conversion of 1,4-alkynediols into pyrroles

Journal

TETRAHEDRON LETTERS
Volume 48, Issue 29, Pages 5115-5120

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.05.070

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Funding

  1. Engineering and Physical Sciences Research Council [GR/S87355/01] Funding Source: researchfish

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Various 1,2,5-substituted pyrroles have been synthesised from 1,4-alkynediols using a ruthenium catalysed isomerisation to give the corresponding 1,4-dicarbonyl compounds, which undergo in situ cyclisation to pyrroles in the presence of amine. (C) 2007 Published by Elsevier Ltd.

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