Journal
TETRAHEDRON
Volume 63, Issue 29, Pages 6855-6860Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.04.062
Keywords
pullularia sp; antiplasmodial activity; antiviral activity; cyclodepsipeptides
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Four new cyclohexadepsipeptides, pullularins A-D, were isolated from the endophytic fungus Pullularia sp. BCC 8613. Structures of these compounds were elucidated by interpretation of NMR spectroscopic and mass spectrometric data. The absolute configurations of amino acid and hydroxy acid residues were determined by HPLC analysis of depsipeptide acid hydrolyzates using a chiral column and Marfey's method. Pullularin A exhibited activities against the malarial parasite Plasmodium falciparum K1 ( IC50 3.6 mu g/mL) and herpes simplex virus type 1 (HSV-1; IC50 3.3 mu g/mL), whereas it showed weak cytotoxicity to Vero cells (IC50 36 mu g/mL). (c) 2007 Elsevier Ltd. All rights reserved.
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