Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 28, Pages 8710-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja073055a
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM068649, R01 GM068649-07] Funding Source: Medline
Ask authors/readers for more resources
We report enantioselective epoxidation reactions that are catalyzed by aspartic acid-containing peptides. The strategy involves the transient conversion of the aspartate carboxylic acid side chain to the corresponding peracid. Reaction of olefin with the activated catalyst regenerates that catalyst, which may be subjected to multiple turnovers through a carbodiimide-mediated dehydration pathway. Enantioselectivities of up to 92% ee are observed for a class of urethane-substituted olefins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available