Journal
NEUROSCIENCE LETTERS
Volume 422, Issue 3, Pages 158-163Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.05.061
Keywords
transmissible spongiform encephalopathies (TSEs); oxidative stress; neurodegeneration; iron regulatory proteins (IRPs); ferritin; Astrocytosis
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Funding
- NIGMS NIH HHS [R01 GM045201-15, R01 GM045201] Funding Source: Medline
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Considerable evidence suggests that oxidative stress may be involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). To investigate the involvement of iron metabolism in TSEs, we examined the expression levels of iron regulatory proteins (IRPs), ferritins, and binding activities of IRPs to iron-responsive element (IRE) in scrapie-infected mice. We found that the IRPs-IRE-binding activities and ferritins were increased in the astrocytes of hippocampus and cerebral cortex in the brains of scrapie-infected mice. These results suggest that alteration of iron metabolism contributes to development of neurodegeneration and that some protective mechanisms against iron-induced oxidative damage may occur during the pathogenesis of TSEs. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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