Journal
ORGANIC LETTERS
Volume 9, Issue 15, Pages 2775-2777Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol070780h
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Funding
- NIGMS NIH HHS [GM57464, GM64346, U54 GM064346, R01 GM057464] Funding Source: Medline
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Merocyanine dyes have proven valuable for live cell fluorescence imaging applications, but many structures have been limited by rapid photobleaching. We show that photostability is substantially enhanced for merocyanines having a cyano group at a specific position in the central polymethine chain. Evidence is presented that this is due to reduction in reactivity of the dyes with singlet oxygen. These results point toward cyano-substitution as a general strategy for improving dye performance in imaging applications.
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