4.7 Article

Synthesis of hyaluronic acid oligomers using Ph2SO/Tf2O-mediated glycosylations

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 15, Pages 5737-5742

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo070704s

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The synthesis of hyaluronic acid (HA) oligomers using a stepwise glycosylation strategy is described. This method employs protected 1-hydroxyuronic acid and 1-phenylthio glucosamine donors, both of which are activated with the Ph2SO/Tf2O activator system.

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