Journal
TETRAHEDRON LETTERS
Volume 48, Issue 30, Pages 5235-5238Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.05.134
Keywords
Phialocephala sp.; trisorbicillinone A; cytotoxicity; fungus
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A novel sorbicillin trimer, trisorbicillinone A (1), was isolated from a deep sea fungus, Phialocephala sp. FL30r. The structure and relative stereochemistry of 1 were determined based on spectroscopic methods. Trisorbicillinone A (1) showed cytotoxicity against P388 and HL60 cells with the IC50 value of 9.10 and 3.14 mu M, respectively. (c) 2007 Elsevier Ltd. All rights reserved.
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