Journal
TETRAHEDRON LETTERS
Volume 48, Issue 30, Pages 5209-5212Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.05.141
Keywords
piperidines; PASE; one-pot; multi-component
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The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves mixing methyl acetoacetate, 2 equiv of aldehyde and 2 equiv of aniline together in the presence of InCl3. In most cases the piperidine precipitates out of solution. (c) 2007 Elsevier Ltd. All rights reserved.
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