Journal
FEBS LETTERS
Volume 581, Issue 18, Pages 3545-3549Publisher
WILEY
DOI: 10.1016/j.febslet.2007.06.052
Keywords
mitofilin; SAM50; metaxin 1; metaxin 2; CHCHD3; CHCHD6 DnaJC11; monoclonal antibody; mitochondria; protein import; sorting and assembly
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A monoclonal antibody (mAb) has been produced which reacts with human mitofilin, a mitochondrial inner membrane protein. This mAb immunocaptures its target protein in association with six other proteins, metaxins I and 2, SAM50, CHCHD3, CHCHD6 and DnaJCI 1, respectively. The first three are outer membrane proteins, CHCHD3 has been assigned to the matrix space, and the other two proteins have not been described in mitochondria previously. The functional role of this new complex is uncertain. However, a role in protein import related to maintenance of mitochondrial structure is suggested as mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins I and 2, SAM50 and CHCHD3) have been implicated in protein import, while DnaJCI I is a chaperone-like protein that may have a similar role. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier BN. All rights reserved.
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