Journal
SCIENCE
Volume 317, Issue 5837, Pages 493-496Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1143272
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM 50174] Funding Source: Medline
Ask authors/readers for more resources
Products of unfavorable chemical equilibria are not readily observed because their high energy and increased reactivity result in low concentrations. Biological macromolecules use binding forces to access unfavorable equilibria and stabilize reactive intermediates by isolating them from the medium. In a similar vein, we describe here a synthetic receptor that allows direct observation of labile tetrahedral intermediates: hemiaminals formed in the reaction of an aldehyde carbonyl group with amines. The receptor encapsulates alkyl-substituted primary amines, then orients them toward a covalently tethered aldehyde function. The hemiaminal intermediates appear at high concentration, confined from the bulk solution and observable at ambient temperature by conventional nuclear magnetic resonance spectroscopy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available