Journal
CELL
Volume 130, Issue 2, Pages 223-233Publisher
CELL PRESS
DOI: 10.1016/j.cell.2007.07.003
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Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage. Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.
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