4.4 Article

Sc(OTf)3-catalyzed alkylation of indoles with propargyl alcohols:: an expeditious synthesis of 3-substituted indoles

Journal

TETRAHEDRON LETTERS
Volume 48, Issue 31, Pages 5573-5576

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.04.056

Keywords

scandium(III) triflate; propargyl alcohols; indoles; alkylation

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Indoles undergo smooth alkylation with propargylic alcohols in the presence of 10 mol % of scandium triflate under mild conditions to produce 3-propargylated indoles in excellent yields with high selectivity. (C) 2007 Published by Elsevier Ltd.

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