Journal
APPLIED PHYSICS LETTERS
Volume 91, Issue 5, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.2766835
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Funding
- Engineering and Physical Sciences Research Council [EP/C536037/1, EP/D04877X/1] Funding Source: researchfish
- EPSRC [EP/D04877X/1] Funding Source: UKRI
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The ability to permeate selectively the cell membrane and introduce therapeutic agents is a key goal in cell biology. Optical transfection is a powerful methodology but requires exact focusing due to the required two-photon power density. The authors use a Bessel beam that obviates the need to locate precisely the cell membrane, permitting two-photon excitation along a line leading to cell transfection. Assuming a minimum efficiency of 20%, the Bessel beam offers transfection at axial distances 20 times greater than that of its Gaussian equivalent. Furthermore, the authors demonstrate cell transfection beyond obstacles due to the self-healing nature of the Bessel beam. (C) 2007 American Institute of Physics.
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