Journal
JOURNAL OF CELL BIOLOGY
Volume 178, Issue 3, Pages 453-464Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200608033
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Funding
- NIDDK NIH HHS [R56 DK052057, DK052057, R01 DK052057] Funding Source: Medline
- NIGMS NIH HHS [R01 GM075252, R01 GM073016, GM075252, GM073016] Funding Source: Medline
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Whether coat proteins play a widespread role in endocytic recycling remains unclear. We find that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings, stimulation-dependent recycling of integrin that is critical for cell migration and insulin-stimulated recycling of glucose transporter type 4 (Glut4), which is required for glucose homeostasis. These findings not only advance a basic understanding of an early mechanistic step in endocytic recycling but also shed key mechanistic insights into major physiological events for which this transport plays a critical role.
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