Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 59, Issue 7, Pages 667-676Publisher
ELSEVIER
DOI: 10.1016/j.addr.2007.05.006
Keywords
lipid-based formulations; drug solubility; lipid excipients; lipid digestion; drug absorption; surfactant; drug delivery
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Poor drug solubility remains a significant and frequently encountered problem for pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal absorption of many poorly soluble drug candidates has been thoroughly documented in the published literature. However, a considerable gap exists between our knowledge of this technology and the know-how required for its application. This commentary provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives. The characteristics of currently available lipid excipients are reviewed in context of their application to the basic lipid-based formulation modalities. The fundamental concepts of in vitro and in vivo evaluation of lipid-based formulations are summarized followed by a forward-looking summary of unrealized opportunities and potential limitations to more widespread use of this technology. (c) 2007 Elsevier B.V. All rights reserved.
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