Journal
FEBS LETTERS
Volume 581, Issue 19, Pages 3716-3722Publisher
WILEY
DOI: 10.1016/j.febslet.2007.04.082
Keywords
heat shock proteins; T cells; immunologic tolerance; cell stress; adjuvant arthritis; immuno-therapy
Ask authors/readers for more resources
T cell responses to heat shock proteins (HSP) have disease suppressive activities through production of anti-inflammatory cytokines in patients and in models of inflammatory diseases. There is evidence that the anti-inflammatory activity of HSP-specific T cells depends on their recognition of endogenous HSP epitopes as expressed by stressed cells at sites of inflammation. Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available