Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 119, Issue 3, Pages 344-348Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2006.07.191
Keywords
Heart failure; Endothelial progenitor cells; Brain natriuretic peptide
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan Tokyo, Japan [15590769]
- Grants-in-Aid for Scientific Research [15590769] Funding Source: KAKEN
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Background: Endothelial progenitor cells (EPCs) circulate in the adult peripheral blood and contribute to neovascularization. EPCs are considered to be included in CD34 positive mononuclear cells (CD34(+) MNCs). Kinetics of circulating EPCs in congestive heart failure (CHF) has not been fully investigated. Methods: We determined the numbers of white blood cells (WBCs), plasma brain natriuretic peptide (BNP), serum erythropoietin, vascular endothelial growth factor (VEGF) and thrombomodulin levels in 16 mild CHF patients (NYHA I, II), 10 severe CHF patients with acute exacerbation (NYHA III, IV), and 22 control subjects. The number of CD34(+) MNCs in peripheral blood was quantified by flow cytometry. Results: The ratio of CD34(+) MNCs: 10(3) WBCs in mild CHF patients was higher than that in control subjects (Pb0.05). Interestingly, the ratio of CD34(+) MNCs: 10(3) WBCs in severe CHF patients at admission was significantly lower than that in control subjects (P<0.005) or in mild CHF patients (P<0.05). Levels of BNP and erythropoietin in severe CHF patients were significantly higher than those in mild CHF patients. However, VEGF and thrombomodulin levels were not different between mild and severe CHF patients. In addition, the ratio of CD34+ MNCs: 10(3) WBCs in severe CHF patients increased in proportion to the amelioration of CHF during hospitalization, and this increase correlated with the decrease in BNP level. Conclusions: The ratio of CD34(+) MNCs: 10(3) WBCs was decreased in severe CHF. These findings suggest that impaired EPC recruitment might be involved in the pathophysiology of severe CHF. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
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