Journal
FEBS LETTERS
Volume 581, Issue 19, Pages 3641-3651Publisher
WILEY
DOI: 10.1016/j.febslet.2007.04.045
Keywords
endoplasmic reticulum; chaperones; mammalian; development; diseases
Funding
- NCI NIH HHS [R01 CA027607, R01 CA111700-03, R01 CA027607-26, R01 CA111700, CA27607, CA111700] Funding Source: Medline
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The field of endoplasmic reticulum (ER) stress in mammalian cells has expanded rapidly during the past decade, contributing to understanding of the molecular pathways that allow cells to adapt to perturbations in ER homeostasis. One major mechanism is mediated by molecular ER chaperones which are critical not only for quality control of proteins processed in the ER, but also for regulation of ER signaling in response to FIR stress. Here, we summarized the properties and functions of GRP78/BiP, GRP94/gp96, GRP170/ORP150, GRP58/ERp57, PDI, ERp72, calnexin, calreticulin, EDEM, Herp and co-chaperones SILI and P58(IPK) and their role in development and diseases. Many of the new insights are derived from recently constructed mouse models where the genes encoding the chaperones are genetically altered, providing invaluable tools for examining the physiological involvement of the ER chaperones in vivo. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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