Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 31, Pages 12596-12602Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0610081104
Keywords
biophysics; microscopy; superresolution; trapping
Categories
Funding
- NCRR NIH HHS [R21 RR023149-01, 1R21 RR 023149, R21 RR023149-02, R21 RR023149] Funding Source: Medline
- NHGRI NIH HHS [P20 HG003638, 1P20 HG 003638, P20 HG003638-04] Funding Source: Medline
- NIGMS NIH HHS [R21 GM075166-02, 1R21 GM 075166, R21 GM075166] Funding Source: Medline
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Optical imaging and analysis of single molecules continue to unfold as powerful ways to study the individual behavior of biological systems, unobscured by ensemble averaging. Current expansion of interest in this field is great, as evidenced by new meetings, journal special issues, and the large number of new investigators. Selected recent advances in biomolecular analysis are described, and two new research directions are summarized: superresolution imaging using single-molecule fluorescence and trapping of single molecules in solution by direct suppression of Brownian motion.
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